I am generally a big fan of my Logitech Harmony 880 remote. I recently made some changes to my home theater setup, and needed to make some changes to the remote. I logged into the Harmony members website, changed my configuration, and uploaded the new configuration to the remote.
The remote rebooted, and then displayed Go to Website to update settings. None of the buttons would work, and even pulling the battery and upgrading the firmware wouldn't get it to do anything.
Turns out there is a problem with Firefox on the Mac that causes this. A quick switch to Safari and clicking Update Remote solved the problem.